Rapid Antigen Test for Pandemic (H1N1) 2009 Virus
نویسندگان
چکیده
To the Editor: Drexler et al. recently compared the sensitivity of the BinaxNOW Influenza A & B Rapid Test (BinaxNOW; Inverness Medical, Cologne, Germany) with that of a real-time reverse transcription–PCR (RT-PCR) assay specific for influenza A pandemic (H1N1) 2009 virus (1). Of 1,838 clinical specimens tested, 221 were confirmed as positive for pandemic (H1N1) 2009 by RT-PCR. When 144 of these 221 specimens were evaluated by using the BinaxNOW, results were positive for only 16 (11%).
منابع مشابه
Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus
Influenza A pandemic (H1N1) 2009 virus RNA was detected by reverse transcription-PCR in 144 clinical samples from Bonn, Germany. A common rapid antigen-based test detected the virus in only 11.1% of these samples. The paramount feature of rapid test-positive samples was high virus concentration. Antigen-based rapid tests appear unsuitable for virologic diagnostics in the current pandemic.
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We compared the QuickVue Influenza test with PCR for diagnosing pandemic (H1N1) 2009 in 404 persons with influenza-like illness. Overall sensitivity, specificity, and positive and negative predictive values were 66%, 84%, 84%, and 64%, respectively. Rapid test results should be interpreted cautiously when pandemic (H1N1) 2009 virus is suspected.
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The rapid diagnosis of influenza is critical in optimizing clinical management. Rapid antigen tests have decreased sensitivity in detecting pandemic influenza A/H1N1 2009 virus compared to seasonal influenza A subtypes (53.4% versus 74.2%, P < 0.001). Nucleic acid tests should be used to detect pandemic influenza virus when rapid antigen tests are negative.
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We evaluated the SD Bioline Influenza Ag A/B/A(H1N1) Pandemic test kit and compared it with real-time reverse transcriptase PCR (RT-PCR) for its ability to detect H1N1 2009. The sensitivity and specificity of the test kit for H1N1 2009 were 77% and 100%, respectively.
متن کاملClinical characteristics of 2009 pandemic influenza A (H1N1) infection in children and the performance of rapid antigen test
PURPOSE In autumn 2009, the swine-origin influenza A (H1N1) virus spread throughout South Korea. The aims of this study were to determine the clinical characteristics of children infected by the 2009 H1N1 influenza A virus, and to compare the rapid antigen and real-time polymerase chain reaction (PCR) tests. METHODS We conducted a retrospective review of patients ≥18 years of age who presente...
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عنوان ژورنال:
دوره 16 شماره
صفحات -
تاریخ انتشار 2010